Article
A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia.
Human molecular genetics - 1 Apr 1997
Arinami T, Gao M, Hamaguchi H, Toru M
Abstract excerpt
An excess dopaminergic activity may be implicated in the etiology of schizophrenia. Our objective was to identify nucleotide variants in the 5' region of the dopamine D2 receptor gene (DRD2) and to clarify their effects on schizophrenia. We identified two polymorphisms, the A-241G and -141C Ins/Del, by examination of 259 bp in the 5'-flanking region and 249 bp of exon 1 of DRD2. Reporter constructs containing the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.