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Article

Disregulation of p16MTS1/CDK4I protein and mRNA expression is associated with gene alterations in squamous-cell carcinoma of the larynx.

International journal of cancer - 31 May 1999

Jares P, Nadal A, Fernández P L, Pinyol M, Hernández L, Cazorla M, Hernández S, Beà S, Cardesa A, Campo E

Abstract excerpt

To determine the relationship between p16MTS1/CDK4I expression, gene inactivation and 9p21 loss of heterozygosity (LOH) in the development of laryngeal carcinomas, we have examined p16MTS1/CDK4I protein and mRNA expression in a series of 7 normal and 36 tumoral tissues, and the presence of gene alterations and 9p21 LOH. Fifteen tumors (42%) showed low levels of pl6MTS1/CDK4I protein expression (similar to normal...

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Identifiers

PMID: 10328220
DOI: 10.1002/(sici)1097-0215(19990531)81:5<705::aid-ijc6>3.0.co;2-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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