Article
Mutations of the cell cycle regulatory genes p16INK4A and p21WAF1 and the metastasis-inducing gene S100A4 are infrequent and unrelated to p53 tumour suppressor gene status and data on survival in oropharyngeal squamous cell carcinomas.
Anticancer research - 1 Jan 2000
Ibrahim Salah Osman, Lillehaug Johan Rikard, Vasstrand Endre Normann
Abstract excerpt
BACKGROUND: Oropharyngeal squamous cell carcinoma (SCC) is probably the most serious cancer to be encountered in the clinic. MATERIALS AND METHODS: Exons 1-3 of the p16 and exon 2 of the p21 genes were examined for mutations by polymerase chain reaction (PCR)/direct DNA sequencing methods in 21 fresh-frozen tissue specimens of oropharyngeal SCCs previously studied for expression and mutation (exons 5-9) of the...
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