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Article

Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications.

Human pathology - 1 Sept 1999

El-Naggar A K, Lai S, Clayman G L, Zhou J H, Tucker S A, Myers J, Luna M A, Benedict W F

Abstract excerpt

Cyclin D1, p16, and Rb genes play a critical role in the regulation of the G1-S transition of the cell cycle and are frequently altered in several neoplastic entities. Analysis of the protein products of these genes by molecular and immunohistochemical methods provides information on their functional status and allows for the phenotypic evaluation of tumor cells. We performed Western blotting and...

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Source

Identifiers

PMID: 10492034
DOI: 10.1016/s0046-8177(99)90217-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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