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Article

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling.

Science (New York, N.Y.) - 14 May 1999

Sabatini D M, Barrow R K, Blackshaw S, Burnett P E, Lai M M, Field M E, Bahr B A, Kirsch J, Betz H, Snyder S H

Abstract excerpt

RAFT1 (rapamycin and FKBP12 target 1; also called FRAP or mTOR) is a member of the ATM (ataxia telangiectasia mutated)-related family of proteins and functions as the in vivo mediator of the effects of the immunosuppressant rapamycin and as an important regulator of messenger RNA translation. In mammalian cells RAFT1 interacted with gephyrin, a widely expressed protein necessary for the clustering of glycine...

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Identifiers

PMID: 10325225
DOI: 10.1126/science.284.5417.1161

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ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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