Article
The Vam6 GEF controls TORC1 by activating the EGO complex.
Molecular cell - 11 Sept 2009
Binda Matteo, Péli-Gulli Marie-Pierre, Bonfils Grégory, Panchaud Nicolas, Urban Jörg, Sturgill Thomas W, Loewith Robbie, De Virgilio Claudio
Abstract excerpt
The target of rapamycin complex 1 (TORC1) is a central regulator of eukaryotic cell growth that is activated by a variety of hormones (e.g., insulin) and nutrients (e.g., amino acids) and is deregulated in various cancers. Here, we report that the yeast Rag GTPase homolog Gtr1, a component of the vacuolar-membrane-associated EGO complex (EGOC), interacts with and activates TORC1 in an amino-acid-sensitive manner....
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