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Article

GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1.

International journal of molecular sciences - 8 Feb 2024

Muller Maéline, Bélanger Jasmine, Hadj-Aissa Imane, Zhang Conghao, Sephton Chantelle F, Dutchak Paul A

Abstract excerpt

GATOR1 (GAP Activity TOward Rag 1) is an evolutionarily conserved GTPase-activating protein complex that controls the activity of mTORC1 (mammalian Target Of Rapamycin Complex 1) in response to amino acid availability in cells. Genetic mutations in the GATOR1 subunits, NPRL2 (nitrogen permease regulator-like 2), NPRL3 (nitrogen permease regulator-like 3), and DEPDC5 (DEP domain containing 5), have been associated...

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Identifiers

PMID: 38396745
DOI: 10.3390/ijms25042068
PMCID: PMC10889792

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