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Article

Regulation of mTORC1 by the Rab and Arf GTPases.

The Journal of biological chemistry - 25 Jun 2010

Li Li, Kim Eunjung, Yuan Haixin, Inoki Ken, Goraksha-Hicks Pankuri, Schiesher Rachel L, Neufeld Thomas P, Guan Kun-Liang

Abstract excerpt

The mammalian target of rapamycin (mTOR) is a key cell growth regulator, which forms two distinct functional complexes (mTORC1 and mTORC2). mTORC1, which is directly inhibited by rapamycin, promotes cell growth by stimulating protein synthesis and inhibiting autophagy. mTORC1 is regulated by a wi...

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Source

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Identifiers

PMID: 20457610
DOI: 10.1074/jbc.C110.102483
PMCID: PMC2888380

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20457610-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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