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Article

Mutational analysis of activin/transforming growth factor-beta type I and type II receptor kinases in human pituitary tumors.

The Journal of clinical endocrinology and metabolism - 1 May 1999

D'Abronzo F H, Swearingen B, Klibanski A, Alexander J M

Abstract excerpt

Genetic mutation or loss of activin/transforming growth factor-beta (TGFbeta) receptor function has been shown in human lymphoid, breast, and colorectal tumors as well as Hep2B and Mv1Lu cell lines. Although activin stimulates FSHbeta biosynthesis and secretion, a large percentage of human gonadotroph tumors have previously been demonstrated to be nonresponsive to characterized activin effects. This phenotype may...

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Identifiers

PMID: 10323406
DOI: 10.1210/jcem.84.5.5704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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