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Article

Role of BAX mutations in mismatch repair-deficient colorectal carcinogenesis.

Oncogene - 25 Mar 1999

Abdel-Rahman W M, Georgiades I B, Curtis L J, Arends M J, Wyllie A H

Abstract excerpt

BAX gene mutations occur in approximately 50% of RER+ colorectal cancers. To determine the role of these mutations in tumour progression we analysed multiple different tumour sites from RER+ colorectal cancers for BAX mutations. Sixty colorectal carcinomas were analysed for microsatellite instability at loci BAT-26, L-myc, TGF betaRII, D13S160 and D2S123. Twelve out of 60 tumours (20%) were RER+. Forty-five...

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Topics

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Share to bcl-2-Associated X Protein
Share to Cell Transformation, Neoplastic
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

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Share to Microsatellite Repeats

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-bcl-2

Source

Identifiers

PMID: 10321738
DOI: 10.1038/sj.onc.1202589

Genes

BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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