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Article

Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion.

The Journal of cell biology - 7 Jan 2002

Calautti Enzo, Grossi Maddalena, Mammucari Cristina, Aoyama Yumi, Pirro Maria, Ono Yoshitaka, Li Jie, Dotto G Paolo

Abstract excerpt

The Rho GTPase and Fyn tyrosine kinase have been implicated previously in positive control of keratinocyte cell-cell adhesion. Here, we show that Rho and Fyn operate along the same signaling pathway. Endogenous Rho activity increases in differentiating keratinocytes and is required for both Fyn kinase activation and increased tyrosine phosphorylation of beta- and gamma-catenin, which is associated with the...

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Identifiers

PMID: 11777936
DOI: 10.1083/jcb.200105140
PMCID: PMC2173591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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