Article
Non-random allelic losses at 3p, 11p and 13q during HPV-mediated immortalization and concomitant loss of terminal differentiation of human keratinocytes.
International journal of cancer - 4 May 1998
Steenbergen R D, Hermsen M A, Walboomers J M, Meijer G A, Baak J P, Meijer C J, Snijders P J
Abstract excerpt
To obtain a comprehensive overview of chromosomal alterations that may underlie human papillomavirus (HPV)-mediated immortalization, 4 foreskin keratinocyte cell lines generated by transfection with either HPV 16 (cell lines FK16A and FK16B) or HPV 18 (FK18A and FK18B) were subjected to chromosom...
Topics
- Alleles
- Cell Differentiation
- Cell Transformation, Viral
- Chromosome Aberrations
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 13
- Chromosomes, Human, Pair 3
- Humans
- Keratinocytes
- Loss of Heterozygosity
- Papillomaviridae
- Tumor Cells, Cultured