Article
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Molecular and cellular biology - 1 Jul 2002
Rheinwald James G, Hahn William C, Ramsey Matthew R, Wu Jenny Y, Guo Zongyou, Tsao Hensin, De Luca Michele, Catricalà Caterina, O'Toole Kathleen M
Abstract excerpt
With increasing frequency during serial passage in culture, primary human keratinocytes express p16(INK4A) (p16) and undergo senescence arrest. Keratinocytes engineered to express hTERT maintain long telomeres but typically are not immortalized unless, by mutation or other heritable event, they avoid or greatly reduce p16 expression. We have confirmed that keratinocytes undergo p16-related senescence during...
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