Article
Immortalization of four new Fanconi anemia fibroblast cell lines by an improved procedure.
Somatic cell and molecular genetics - 1 Mar 1996
Jakobs P M, Sahaayaruban P, Saito H, Reifsteck C, Olson S, Joenje H, Moses R E, Grompe M
Abstract excerpt
Fanconi anemia (FA) is an autosomal recessive disease characterized by birth defects, progressive bone marrow failure and increased risk for leukemia. FA cells display chromosome breakage and increased cell killing in response to DNA crosslinking agents. At least 5 genes have been defined by cell...
Topics
- Cell Culture Techniques
- Cell Fusion
- Cell Line, Transformed
- Cell Survival
- Chromosome Aberrations
- Epoxy Compounds
- Ethyl Methanesulfonate
- Fanconi Anemia
- Fibroblasts
- Genetic Complementation Test
- Humans
- Karyotyping
- Mitomycin
- Mutagens
- Phenotype
- Skin