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Article

Independent FHC-related cardiac troponin T mutations exhibit specific alterations in myocellular contractility and calcium kinetics.

Journal of molecular and cellular cardiology - 1 Jun 2007

Haim Todd E, Dowell Candice, Diamanti Theodhor, Scheuer James, Tardiff Jil C

Abstract excerpt

Mutations in cardiac troponin T (cTnT) are linked to a severe form of Familial Hypertrophic Cardiomyopathy. Patients carrying mutations flanking the tropomyosin-binding domain of cTnT (R92L and Delta160E) develop distinct clinical syndromes. In order to better understand the cellular pathophysiology underlying these clinically relevant differences, we studied isolated adult left ventricular myocytes from...

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Identifiers

PMID: 17490679
DOI: 10.1016/j.yjmcc.2007.03.906

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