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Article

Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy.

Circulation - 10 May 2005

Sanbe Atsushi, James Jeanne, Tuzcu Volkan, Nas Selman, Martin Lisa, Gulick James, Osinska Hanna, Sakthivel Sadayappan, Klevitsky Raisa, Ginsburg Kenneth S, Bers Donald M, Zinman Bruce, Lakatta Edward G, Robbins Jeffrey

Abstract excerpt

BACKGROUND: Transgenic and gene-targeted models have focused on the mouse. Fundamental differences between the mouse and human exist in Ca2+ handling during contraction/relaxation and in alterations in Ca2+ flux during heart failure, with the rabbit more accurately reflecting the human system. METHODS AND RESULTS: Cardiac troponin I (cTnI) mutations can cause familial hypertrophic cardiomyopathy. An inhibitory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15867176
DOI: 10.1161/01.CIR.0000164234.24957.75
PMCID: PMC1314982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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