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Article

Myofilament calcium sensitivity and cardiac disease: insights from troponin I isoforms and mutants.

Circulation research - 20 Sept 2002

Westfall Margaret V, Borton Andrea R, Albayya Faris P, Metzger Joseph M

Abstract excerpt

The heightened Ca2+ sensitivity of force found with hypertrophic cardiomyopathy (HCM)-associated mutant cardiac troponin I (cTnIR145G; R146G in rodents) has been postulated to be an underlying cause of hypertrophic growth and premature sudden death in humans and in animal models of the disease. Expression of slow skeletal TnI (ssTnI), a TnI isoform naturally expressed in developing heart, also increases...

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Source

Identifiers

PMID: 12242271
DOI: 10.1161/01.res.0000034710.46739.c0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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