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Article

Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation.

The Journal of biological chemistry - 9 Feb 2001

Miller T, Szczesna D, Housmans P R, Zhao J, de Freitas F, Gomes A V, Culbreath L, McCue J, Wang Y, Xu Y, Kerrick W G, Potter J D

Abstract excerpt

This study characterizes a transgenic animal model for the troponin T (TnT) mutation (I79N) associated with familial hypertrophic cardiomyopathy. To study the functional consequences of this mutation, we examined a wild type and two I79N-transgenic mouse lines of human cardiac TnT driven by a mur...

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PMID: 11060294
DOI: 10.1074/jbc.M006746200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11060294-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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