Article
Evidence for multiple promoter elements orchestrating male-specific regulation of the her-1 gene in Caenorhabditis elegans.
Genetics - 1 May 1999
Li W, Streit A, Robertson B, Wood W B
Abstract excerpt
The sex-determining gene her-1 is required for male development in Caenorhabditis elegans. In XO males, two her-1 mRNAs, her-1a and her-1b, are transcribed from two separate promoters: P1, located in the 5'-flanking region, and P2, located in the large second intron. In XX hermaphrodites, accumulation of both her-1 transcripts is repressed by the sdc genes, which in turn are negatively regulated by the xol-1...
Topics
- Animals
- Blotting, Southern
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Crosses, Genetic
- Dosage Compensation, Genetic
- Gene Expression Regulation
- Genes, Lethal
- Helminth Proteins
- Male
- Microscopy, Interference
- Models, Genetic
- Mutagenesis