Article
Extragenic suppressors of a dominant masculinizing her-1 mutation in C. elegans identify two new genes that affect sex determination in different ways.
Genesis (New York, N.Y. : 2000) - 1 Nov 2002
Manser James, Wood William B, Perry Marc D
Abstract excerpt
SUMMARY: The her-1 regulatory switch gene in C. elegans sex determination is normally active in XO animals, resulting in male development, and inactive in XX animals, allowing hermaphrodite development. The her-1(n695gf) mutation results in the incomplete transformation of XX animals into phenotypic males. We describe four extragenic mutations that suppress the masculinized phenotype of her-1(n695gf) XX. They...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- DNA-Binding Proteins
- Dosage Compensation, Genetic
- Genes, Suppressor
- Helminth Proteins
- Membrane Proteins
- Mutation
- Sex Determination Processes
- Transcription Factors
- X Chromosome