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Article

A molecular link between gene-specific and chromosome-wide transcriptional repression.

Genes & development - 1 Apr 2002

Chu Diana S, Dawes Heather E, Lieb Jason D, Chan Raymond C, Kuo Annie F, Meyer Barbara J

Abstract excerpt

Gene-specific and chromosome-wide mechanisms of transcriptional regulation control development in multicellular organisms. SDC-2, the determinant of hermaphrodite fate in Caenorhabditis elegans, is a paradigm for both modes of regulation. SDC-2 represses transcription of X chromosomes to achieve dosage compensation, and it also represses the male sex-determination gene her-1 to elicit hermaphrodite...

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Share to Caenorhabditis elegans Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11937488
DOI: 10.1101/gad.972702
PMCID: PMC186330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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