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Article

A novel regulatory mutation in the C. elegans sex determination gene tra-2 defines a candidate ligand/receptor interaction site.

Development (Cambridge, England) - 1 Jul 1996

Kuwabara P E

Abstract excerpt

Sex determination in the nematode C. elegans is dependent on cell-to-cell communication, which appears to be mediated by the predicted membrane protein TRA-2A and the secreted protein HER-1. In XO males, HER-1 is hypothesised to function as a repressive ligand that inactivates the TRA-2A receptor. In XX animals, HER-1 is absent and TRA-2A promotes hermaphrodite development by negatively regulating the FEM...

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Identifiers

PMID: 8681790
DOI: 10.1242/dev.122.7.2089

Genes

TRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel regulatory mutation in the C. elegans sex determination gene tra-2 defines a candidate ligand/receptor interaction site.PMID 8681790Read ↗

Direct protein-protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans.Semantic proximity Read ↗

A predicted membrane protein, TRA-2A, directs hermaphrodite development in Caenorhabditis elegans.Semantic proximity Read ↗

Extragenic suppressors of a dominant masculinizing her-1 mutation in C. elegans identify two new genes that affect sex determination in different ways.Semantic proximity Read ↗

Interspecies comparison reveals evolution of control regions in the nematode sex-determining gene tra-2.Semantic proximity Read ↗

Molecular analysis of tra-2, a sex determining gene in C.elegans.Semantic proximity Read ↗

Somatic sex determinationSemantic proximity Read ↗

Isolation of dominant XO-feminizing mutations in Caenorhabditis elegans: new regulatory tra alleles and an X chromosome duplication with implications for primary sex determination.Semantic proximity Read ↗

The tra-1 gene determines sexual phenotype cell-autonomously in C. elegans.Semantic proximity Read ↗

Sequenced alleles of the Caenorhabditis elegans sex-determining gene her-1 include a novel class of conditional promoter mutations.Semantic proximity Read ↗

Dominant feminizing mutations implicate protein-protein interactions as the main mode of regulation of the nematode sex-determining gene tra-1.Semantic proximity Read ↗

Evidence from mosaic analysis of the masculinizing gene her-1 for cell interactions in C. elegans sex determination.Semantic proximity Read ↗

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