Article
A novel regulatory mutation in the C. elegans sex determination gene tra-2 defines a candidate ligand/receptor interaction site.
Development (Cambridge, England) - 1 Jul 1996
Kuwabara P E
Abstract excerpt
Sex determination in the nematode C. elegans is dependent on cell-to-cell communication, which appears to be mediated by the predicted membrane protein TRA-2A and the secreted protein HER-1. In XO males, HER-1 is hypothesised to function as a repressive ligand that inactivates the TRA-2A receptor...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Culture Techniques
- Cloning, Molecular
- Disorders of Sex Development
- Drosophila Proteins
- Feminization
- Gene Expression Regulation, Developmental
- Helminth Proteins
- Ligands
- Male
- Molecular Sequence Data
- Mutation
- Phenotype
- RNA, Messenger