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Article

tRNA synthetase mutants of Escherichia coli K-12 are resistant to the gyrase inhibitor novobiocin.

Journal of bacteriology - 1 May 1999

Jovanovic M, Lilic M, Janjusevic R, Jovanovic G, Savic D J, Milija J

Abstract excerpt

In previous studies we demonstrated that mutations in the genes cysB, cysE, and cls (nov) affect resistance of Escherichia coli to novobiocin (J. Rakonjac, M. Milic, and D. J. Savic, Mol. Gen. Genet. 228:307-311, 1991; R. Ivanisevic, M. Milic, D. Ajdic, J. Rakonjac, and D. J. Savic, J. Bacteriol. 177:1766-1771, 1995). In this work we expand this list with mutations in rpoN (the gene for RNA polymerase subunit...

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Identifiers

PMID: 10217798
DOI: 10.1128/JB.181.9.2979-2983.1999
PMCID: PMC93749

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Source receipt: pubmed, retrieved 7 Sept 2026.

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