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Article

RNA Sequencing Identifies a Common Physiology in Vancomycin- and Ciprofloxacin-Tolerant Staphylococcus aureus Induced by ileS Mutations.

Antimicrobial agents and chemotherapy - 21 Sept 2020

Singh Madhuri, Matsuo Miki, Sasaki Takashi, Hishinuma Tomomi, Yamamoto Norio, Morimoto Yuh, Kirikae Teruo, Hiramatsu Keiichi

Abstract excerpt

Little is known about the mechanisms by which ileS mutations induce vancomycin tolerance in Staphylococcus aureus This study showed that transcriptome profiles were similar in vancomycin-tolerant mutants and the IleRS-inhibitor-treated parent. Notably, ileS and relA, which induce a stringent response, were upregulated. The same mechanism was responsible for cross-tolerance to vancomycin and ciprofloxacin. These...

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PMID: 32690649
DOI: 10.1128/AAC.00827-20
PMCID: PMC7508618

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