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Article

Characterization of Escherichia coli D-cycloserine transport and resistant mutants.

Journal of bacteriology - 1 Apr 2013

Baisa Gary, Stabo Nicholas J, Welch Rodney A

Abstract excerpt

d-Cycloserine (DCS) is a broad-spectrum antibiotic that inhibits d-alanine ligase and alanine racemase activity. When Escherichia coli K-12 or CFT073 is grown in minimal glucose or glycerol medium, CycA transports DCS into the cell. E. coli K-12 cycA and CFT073 cycA mutant strains display increased DCS resistance when grown in minimal medium. However, the cycA mutants exhibit no change in DCS sensitivity compared...

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Identifiers

PMID: 23316042
DOI: 10.1128/JB.01598-12
PMCID: PMC3624533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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