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Article

Accumulation of mutations in both gyrB and parE genes is associated with high-level resistance to novobiocin in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Sept 2005

Fujimoto-Nakamura Mika, Ito Hideaki, Oyamada Yoshihiro, Nishino Takeshi, Yamagishi Jun-Ichi

Abstract excerpt

Coumarin-resistant mutants of Staphylococcus aureus were isolated by three-step selection with novobiocin at different concentrations. Sequencing analysis of the gyrB and parE genes of the first-, second-, and third-step mutants revealed that successive point mutations first occurred specifically in the gyrB gene, followed by a point mutation in the parE gene and then an additional point mutation in the gyrB...

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Identifiers

PMID: 16127057
DOI: 10.1128/AAC.49.9.3810-3815.2005
PMCID: PMC1195401

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Source receipt: pubmed, retrieved 7 Sept 2026.

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