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Article

Genetic and physiological characterization of rpoB mutations that activate antibiotic production in Streptomyces lividans.

Microbiology (Reading, England) - 1 Nov 2002

Lai Caixia, Xu Jun, Tozawa Yuzuru, Okamoto-Hosoya Yoshiko, Yao Xingsheng, Ochi Kozo

Abstract excerpt

Antibiotic production in Streptomyces lividans can be activated by introducing certain mutations (rif) into the rpoB gene that confer resistance to rifampicin. Working with the most typical (rif-17) mutant strain, KO-417, the rif-17 mutation was characterized. The rif-17 mutation was shown to be responsible for activating antibiotic production and for reducing the growth rate of strain KO-417, as demonstrated by...

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PMID: 12427928
DOI: 10.1099/00221287-148-11-3365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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