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Article

Alteration of Escherichia coli topoisomerase IV to novobiocin resistance.

Antimicrobial agents and chemotherapy - 1 Mar 2003

Hardy Christine D, Cozzarelli Nicholas R

Abstract excerpt

DNA gyrase and topoisomerase IV (topo IV) are the two essential type II topoisomerases of Escherichia coli. Gyrase is responsible for maintaining negative supercoiling of the bacterial chromosome, whereas topo IV's primary role is in disentangling daughter chromosomes following DNA replication. Coumarins, such as novobiocin, are wide-spectrum antimicrobial agents that primarily interfere with DNA gyrase. In this...

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Identifiers

PMID: 12604525
DOI: 10.1128/AAC.47.3.941-947.2003
PMCID: PMC149342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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