Penicillin binding protein 2 is dispensable in Escherichia coli when ppGpp synthesis is induced.

doi:10.1002/j.1460-2075.1992.tb05194.x

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Article

Penicillin binding protein 2 is dispensable in Escherichia coli when ppGpp synthesis is induced.

The EMBO journal - 1 Apr 1992

Vinella D, D'Ari R, Jaffé A, Bouloc P

Abstract excerpt

Mecillinam, a beta-lactam antibiotic which specifically inactivates penicillin binding protein 2 (PBP2) in Escherichia coli, prevents lateral cell wall elongation, inducing spherical morphology and cell death. Two mecillinam resistant mutants, lov-1 and lovB, both able to dispense entirely with PBP2, are shown here to be affected in the aminoacyl-tRNA synthetase genes argS and alaS, respectively. Although the...

Topics

Alanine-tRNA Ligase
Alleles
Amdinocillin
Arginine-tRNA Ligase
Bacterial Proteins
Carrier Proteins
Cell Division
Chromosome Mapping
Drug Resistance, Microbial
Escherichia coli
Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Bacterial

Genotype

Guanosine Tetraphosphate

Hexosyltransferases

Multienzyme Complexes

Muramoylpentapeptide Carboxypeptidase

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 1563353
DOI: 10.1002/j.1460-2075.1992.tb05194.x
PMCID: PMC556598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1563353-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Penicillin binding protein 2 is dispensable in Escherichia coli when ppGpp synthesis is induced.PMID 1563353Read ↗

Preliminary physiologic characterization and genetic analysis of a new Escherichia coli mutant, lov, resistant to mecillinam.Semantic proximity Read ↗

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Overproduction of penicillin-binding protein 2 and its inactive variants causes morphological changes and lysis in Escherichia coli.Semantic proximity Read ↗

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