Article
Relationship of protein structure of isoleucyl-tRNA synthetase with pseudomonic acid resistance of Escherichia coli. A proposed mode of action of pseudomonic acid as an inhibitor of isoleucyl-tRNA synthetase.
The Journal of biological chemistry - 30 Sept 1994
Yanagisawa T, Lee J T, Wu H C, Kawakami M
Abstract excerpt
To elucidate the mode of action of pseudomonic acid, we have compared the deduced amino acid sequences of isoleucyl-tRNA synthetases (ILeRS) from wild-type Escherichia coli strain MC4100, a pseudomonic acid-resistant mutant (strain PS102) of MC4100, and a pseudomonic acid-producing strain, Pseudo...
Topics
- Adenosine Triphosphate
- Alleles
- Amino Acid Sequence
- Base Sequence
- DNA Primers
- DNA, Bacterial
- Drug Resistance, Microbial
- Escherichia coli
- Hydrolysis
- Isoleucine-tRNA Ligase
- Molecular Sequence Data
- Mupirocin
- Protein Conformation
- Pseudomonas fluorescens
- Trypsin