cysB and cysE mutants of Escherichia coli K12 show increased resistance to novobiocin.

doi:10.1007/BF00282481

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Article

cysB and cysE mutants of Escherichia coli K12 show increased resistance to novobiocin.

Molecular & general genetics : MGG - 1 Aug 1991

Rakonjac J, Milic M, Savic D J

Abstract excerpt

Mutations in the cysB and cysE genes of Escherichia coli K12 cause an increase in resistance to the gyrase inhibitor novobiocin but not to coumermycin, acriflavine and rifampicin. This unusual relationship was also observed among spontaneous novobiocin resistant (Novr) mutants: 10% of Novr mutant...

Topics

Acetyltransferases
Acriflavine
Aminocoumarins
Bacterial Proteins
Cell Survival
Coumarins
DNA-Binding Proteins
Dose-Response Relationship, Drug
Drug Resistance, Microbial
Escherichia coli
Escherichia coli Proteins
Mutation
Novobiocin
Rifampin
Serine O-Acetyltransferase

Source

Open in PubMed

Identifiers

PMID: 1886615
DOI: 10.1007/BF00282481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1886615-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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