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Article

Bile acids specifically increase hepatitis C virus RNA-replication.

PloS one - 1 Jan 2012

Chhatwal Patrick, Bankwitz Dorothea, Gentzsch Juliane, Frentzen Anne, Schult Philipp, Lohmann Volker, Pietschmann Thomas

Abstract excerpt

BACKGROUND: Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends on lipids and lipoproteins during RNA-replication, virus production and cell entry, BAs may affect multiple steps of...

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PMID: 22558311
DOI: 10.1371/journal.pone.0036029
PMCID: PMC3338857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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