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Article

Hepatocyte Polarization Is Essential for the Productive Entry of the Hepatitis B Virus

28 Sept 2011

Abstract excerpt

UNLABELLED: Human hepatitis B virus (HBV) is characterized by a high species specificity and a distinct liver tropism. Within the liver, HBV replication occurs in differentiated and polarized hepatocytes. Accordingly, the in vitro HBV infection of primary human hepatocytes (PHHs) and the human hepatoma cell line, HepaRG, is restricted to differentiated, hepatocyte-like cells. Though preparations of PHH contain up...

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PMID: 21953491
DOI: 10.1002/hep.24707

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