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Article

Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR.

Journal of hepatology - 1 Feb 2008

Scholtes Caroline, Diaz Olivier, Icard Vinca, Kaul Artur, Bartenschlager Ralf, Lotteau Vincent, André Patrice

Abstract excerpt

BACKGROUND/AIMS: Hepatitis C virus (HCV) infected patients with high serum levels of bile acids (BAs) usually fail to respond to antiviral therapy. Besides, BAs are essential factors for replication of the porcine enteric calicivirus by inhibiting interferon signaling. The role of BAs on HCV RNA replication was thus assessed. METHODS: BAs and other compounds were tested using an HCV-replication model containing a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18096266
DOI: 10.1016/j.jhep.2007.09.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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