Article
Human hepatic stellate cells are not permissive for hepatitis C virus entry and replication.
Gut - 1 Jun 2015
Florimond Alexandre, Chouteau Philippe, Bruscella Patrice, Le Seyec Jacques, Mérour Emilie, Ahnou Nazim, Mallat Ariane, Lotersztajn Sophie, Pawlotsky Jean-Michel
Abstract excerpt
BACKGROUND: Chronic HCV infection is associated with the development of hepatic fibrosis. The direct role of HCV in the fibrogenic process is unknown. Specifically, whether HCV is able to infect hepatic stellate cells (HSCs) is debated. OBJECTIVE: To assess whether human HSCs are susceptible to HCV infection. DESIGN: We combined a set of original HCV models, including the infectious genotype 2a JFH1 model...
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