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Vectorial Entry and Release of Hepatitis A Virus in Polarized Human Hepatocytes

26 Jun 2008

Abstract excerpt

Hepatitis A virus (HAV) is an enterically transmitted virus that replicates predominantly in hepatocytes within the liver before excretion via bile through feces. Hepatocytes are polarized epithelial cells, and it has been assumed that the virus load in bile results from direct export of HAV via the apical domain of polarized hepatocytes. We have developed a subclone of hepatocyte-derived HepG2 cells (clone N6)...

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PMID: 18579610
DOI: 10.1128/jvi.00219-08

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