Article
Cyclin D1 overexpression and p53 mutation status in epithelial ovarian cancer.
Journal of the Society for Gynecologic Investigation - 1 Jan 2000
Shigemasa K, Tanimoto H, Parham G P, Parmley T H, Ohama K, O'Brien T J
Abstract excerpt
OBJECTIVE: To examine the cyclin D1 mRNA expression level in ovarian tumor samples as compared with normal ovaries and to determine the relationship between cyclin D1 overexpression and p53 mutation status in ovarian tumors. METHODS: mRNA was isolated and cDNA was prepared from 27 epithelial ovarian tumors (3 tumors of low malignant potential (LMP) and 24 cancers) and 6 normal ovaries. The cyclin D1 sequences...
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