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Article

p16 overexpression: a potential early indicator of transformation in ovarian carcinoma.

Journal of the Society for Gynecologic Investigation - 1 Jan 2000

Shigemasa K, Hu C, West C M, Clarke J, Parham G P, Parmley T H, Korourian S, Baker V V, O'Brien T J

Abstract excerpt

OBJECTIVE: The recently cloned gene p16 (MST1) has been identified as a putative tumor suppressor gene that binds to CDK4 and CDK6 (cyclin-dependent kinases), preventing their interaction with cyclin D1 and thereby preventing cell cycle progression at the G1 stage. In addition, the p16 gene has been shown to have a high frequency of mutation in some tumor cell lines; however, it has also been shown that a much...

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Source

Identifiers

PMID: 9101469

Genes

CDK4
CDK6
MST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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