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Article

Cyclin D1 gene (CCND1) mutations in endometrial cancer.

Oncogene - 4 Sept 2003

Moreno-Bueno Gema, Rodríguez-Perales Sandra, Sánchez-Estévez Carolina, Hardisson David, Sarrió David, Prat Jaime, Cigudosa Juan C, Matias-Guiu Xavier, Palacios José

Abstract excerpt

Cyclin D1 is frequently overexpressed in human neoplasias by gene rearrangement and amplification, but no mutations in the CCND1 gene have so far been reported. However, in vitro mutagenesis of CCND1 has shown that substitutions affecting threonine 286 residue produced cyclin D1 nuclear accumulation, by interfering with protein degradation and induced neoplastic transformation in murine fibroblasts. To test...

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Identifiers

PMID: 12955092
DOI: 10.1038/sj.onc.1206868

Genes

CCND1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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