Article
Association of downregulation of cyclin D1 and of overexpression of cyclin E with p53 mutation, high tumor grade and poor prognosis in hepatocellular carcinoma.
Journal of hepatology - 1 Aug 1998
Peng S Y, Chou S P, Hsu H C
Abstract excerpt
BACKGROUND/AIMS: The major regulatory events leading to cell proliferation occur in the G1 phase of cell cycle, and the deranged expression of G1 cyclins is related to oncogenesis. In this study, we analyzed the aberrant expressions of cyclins D1 and E, and their role in hepatocellular carcinoma....
Topics
- Carcinoma, Hepatocellular
- Cell Cycle
- Cyclin D1
- Cyclin E
- Disease Progression
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Liver Neoplasms
- Male
- Middle Aged
- Mutation
- Neoplasm Invasiveness
- Prognosis
- RNA, Messenger
- Recurrence
- Retrospective Studies