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Article

Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain.

Molecular cell - 1 Mar 1999

Peyroche A, Antonny B, Robineau S, Acker J, Cherfils J, Jackson C L

Abstract excerpt

We demonstrate that the major in vivo targets of brefeldin A (BFA) in the secretory pathway of budding yeast are the three members of the Sec7 domain family of ARF exchange factors: Gea1p and Gea2p (functionally interchangeable) and Sec7p. Specific residues within the Sec7 domain are important for BFA inhibition of ARF exchange activity, since mutations in these residues of Gea1p (sensitive to BFA) and of ARNO...

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Identifiers

PMID: 10198630
DOI: 10.1016/s1097-2765(00)80455-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain.PMID 10198630Read ↗

Dual specificity of the interfacial inhibitor brefeldin a for arf proteins and sec7 domains.Semantic proximity Read ↗

Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors.Semantic proximity Read ↗

Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway.Semantic proximity Read ↗

Highly conserved motifs within the large Sec7 ARF guanine nucleotide exchange factor GBF1 target it to the Golgi and are critical for GBF1 activity.Semantic proximity Read ↗

Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.Semantic proximity Read ↗

Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes.Semantic proximity Read ↗

Brefeldin A causes a defect in secretion in Saccharomyces cerevisiae.Semantic proximity Read ↗

BFR1, a multicopy suppressor of brefeldin A-induced lethality, is implicated in secretion and nuclear segregation in Saccharomyces cerevisiae.Semantic proximity Read ↗

The ARF exchange factors Gea1p and Gea2p regulate Golgi structure and function in yeast.Semantic proximity Read ↗

Brefeldin A inhibited activity of the sec7 domain of p200, a mammalian guanine nucleotide-exchange protein for ADP-ribosylation factors.Semantic proximity Read ↗

Mutations in a highly conserved region of the Arf1p activator GEA2 block anterograde Golgi transport but not COPI recruitment to membranes.Semantic proximity Read ↗

The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.Semantic proximity Read ↗

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