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Article

Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 1999

Sata M, Moss J, Vaughan M

Abstract excerpt

Protein secretion through the endoplasmic reticulum and Golgi vesicular trafficking system is initiated by the binding of ADP-ribosylation factors (ARFs) to donor membranes, leading to recruitment of coatomer, bud formation, and eventual vesicle release. ARFs are approximately 20-kDa GTPases that...

Topics

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ADP-Ribosylation Factors
Biological Transport
Brefeldin A
Fungal Proteins
Golgi Apparatus
GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Guanine Nucleotide Exchange Factors

Protein Synthesis Inhibitors

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Identifiers

PMID: 10077583
DOI: 10.1073/pnas.96.6.2752
PMCID: PMC15841

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10077583-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors.PMID 10077583Read ↗

Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain.Semantic proximity Read ↗

Brefeldin A inhibited activity of the sec7 domain of p200, a mammalian guanine nucleotide-exchange protein for ADP-ribosylation factors.Semantic proximity Read ↗

Dual specificity of the interfacial inhibitor brefeldin a for arf proteins and sec7 domains.Semantic proximity Read ↗

Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.Semantic proximity Read ↗

Highly conserved motifs within the large Sec7 ARF guanine nucleotide exchange factor GBF1 target it to the Golgi and are critical for GBF1 activity.Semantic proximity Read ↗

Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers.Semantic proximity Read ↗

Similarities in Function and Gene Structure of Cytohesin-4 and Cytohesin-1, Guanine Nucleotide-exchange Proteins for ADP-ribosylation FactorsSemantic proximity Read ↗

Human and Giardia ADP-ribosylation factors (ARFs) complement ARF function in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Inhibitor Endosidin 4 Targets SEC7 Domain-Type ARF GTPase Exchange Factors and Interferes with Subcellular Trafficking in Eukaryotes.Semantic proximity Read ↗

Functional analysis of ADP-ribosylation factor (ARF) guanine nucleotide exchange factors Gea1p and Gea2p in yeast.Semantic proximity Read ↗

Brefeldin A causes a defect in secretion in Saccharomyces cerevisiae.Semantic proximity Read ↗

A novel small molecule regulator of guanine nucleotide exchange activity of the ADP-ribosylation factor and golgi membrane trafficking.Semantic proximity Read ↗

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