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Article

The ARF exchange factors Gea1p and Gea2p regulate Golgi structure and function in yeast.

Journal of cell science - 1 Jun 2001

Peyroche A, Courbeyrette R, Rambourg A, Jackson C L

Abstract excerpt

The Sec7 domain guanine nucleotide exchange factors (GEFs) for the GTPase ARF are highly conserved regulators of membrane dynamics. Their precise molecular roles in different trafficking steps within the cell have not been elucidated. We present a functional analysis of two members of this family, Gea1p and Gea2p, in the yeast Saccharomyces cerevisiae. Gea1p and Gea2p can functionally replace each other, but at...

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Identifiers

PMID: 11493664
DOI: 10.1242/jcs.114.12.2241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The ARF exchange factors Gea1p and Gea2p regulate Golgi structure and function in yeast.PMID 11493664Read ↗

Mutations in a highly conserved region of the Arf1p activator GEA2 block anterograde Golgi transport but not COPI recruitment to membranes.Semantic proximity Read ↗

Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function.Semantic proximity Read ↗

Sec7p directs the transitions required for yeast Golgi biogenesis.Semantic proximity Read ↗

ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization.Semantic proximity Read ↗

Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi.Semantic proximity Read ↗

A novel Golgi membrane protein is a partner of the ARF exchange factors Gea1p and Gea2p.Semantic proximity Read ↗

Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.Semantic proximity Read ↗

Functional analysis of ADP-ribosylation factor (ARF) guanine nucleotide exchange factors Gea1p and Gea2p in yeast.Semantic proximity Read ↗

Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast.Semantic proximity Read ↗

Golgi enlargement in Arf-depleted yeast cells is due to altered dynamics of cisternal maturation.Semantic proximity Read ↗

GBF/Gea mutant with a single substitution sustains fungal growth in the absence of BIG/Sec7.Semantic proximity Read ↗

Establishing a role for the GTPase Ypt1p at the late Golgi.Semantic proximity Read ↗

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