Article
In vitro selection of an archaeal RNase P RNA mimics natural variation.
Archaea (Vancouver, B.C.) - 1 Oct 2004
Williams Daniel, Brown James W
Abstract excerpt
Archaeal and bacterial RNase P RNAs are similar in sequence and secondary structure, but in the absence of protein, the archaeal RNAs are much less active and require extreme ionic conditions for activity. To assess how readily the activity of the archaeal RNA alone could be improved by small changes in sequence, in vitro selection was used to generate variants of a Methanobacterium formicicum RNase P RNA:...
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