Article
Inhibition of viral gene expression by human ribonuclease P.
RNA (New York, N.Y.) - 1 Nov 1998
Kawa D, Wang J, Yuan Y, Liu F
Abstract excerpt
External guide sequences (EGSs) are small RNA molecules which consist of a sequence complementary to a target mRNA and render the target RNA susceptible to degradation by ribonuclease P (RNase P). EGSs were designed to target the mRNA encoding thymidine kinase (TK) of herpes simplex virus 1 for d...
Topics
- Animals
- Base Sequence
- Blotting, Western
- Cells, Cultured
- Chlorocebus aethiops
- Endoribonucleases
- Gene Expression Regulation, Viral
- Gene Targeting
- Herpesvirus 1, Human
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- RNA, Catalytic
- RNA, Messenger
- Ribonuclease P
- Ribonucleoproteins
- Thymidine Kinase