Phosphorothioates in pre-tRNAs can change the specificities of RNAses P or reduce the cleavage efficiencies.

doi:10.1016/0300-9084(93)90145-i

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Article

Phosphorothioates in pre-tRNAs can change the specificities of RNAses P or reduce the cleavage efficiencies.

Biochimie - 1 Jan 1993

Kahle D, Küst B, Krupp G

Abstract excerpt

Several phosphorothioate-modified E coli and yeast pre-tRNAs were synthesized. If this modification included the phosphodiester at the RNase P cleavage site, two different effects were observed. With some pre-tRNAs the RNase P cleavage efficiency was severely reduced, whereas with other pre-tRNAs...

Topics

Base Composition
Base Sequence
Endoribonucleases
Escherichia coli
Escherichia coli Proteins
Molecular Sequence Data
Mutation
RNA Precursors
RNA, Catalytic
RNA, Transfer
RNA, Transfer, Amino Acyl
Ribonuclease P
Thionucleosides
Transcription, Genetic
Yeasts

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