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Article

Lead-catalyzed cleavage of yeast tRNAPhe mutants.

Biochemistry - 13 Mar 1990

Behlen L S, Sampson J R, DiRenzo A B, Uhlenbeck O C

Abstract excerpt

Yeast tRNA(Phe) lacking modified nucleotides undergoes lead-catalyzed cleavage between nucleotides U17 and G18 at a rate very similar to that of its fully modified counterpart. The rates of cleavage for 28 tRNA(Phe) mutants were determined to define the structural requirements of this reaction. The cleavage rate was found to be very dependent on the identity and correct positioning of the two lead-coordinating...

Topics

Base Sequence
Binding Sites
Kinetics
Lead
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Nucleic Acid Denaturation
RNA, Transfer, Amino Acid-Specific
RNA, Transfer, Phe
Yeasts

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Identifiers

PMID: 2334679
DOI: 10.1021/bi00462a013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2334679-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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