Article
Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 -163C>A polymorphism.
European journal of clinical pharmacology - 1 Jul 2010
Djordjevic Natasa, Ghotbi Roza, Jankovic Slobodan, Aklillu Eleni
Abstract excerpt
OBJECTIVES: To investigate the association of CYP1A2 genetic polymorphisms with the inducing effect of heavy coffee consumption on CYP1A2 activity in Serbian and Swedish populations, and to determine the frequency of the CYP1A2 genetic polymorphisms in Serbs. METHODS: Using PCR-RFLP and the tag-array minisequencing method, 126 Serbian healthy volunteers were genotyped for -3860G>A, -2467delT, -739T>G, -729C>T,...
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