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Article

Impact of smoking, smoking cessation, and genetic polymorphisms on CYP1A2 activity and inducibility.

Clinical pharmacology and therapeutics - 1 Jul 2011

Dobrinas M, Cornuz J, Oneda B, Kohler Serra M, Puhl M, Eap C B

Abstract excerpt

Cytochrome P4501A2 (CYP1A2) is involved in the metabolism of several drugs and is induced by smoking. We aimed to determine the interindividual change in CYP1A2 activity after smoking cessation and to relate it to CYP1A2 genetic polymorphisms. CYP1A2 activity was determined from the paraxanthine:caffeine ratio in 194 smokers and in 118 of them who had abstained from smoking during a 4-week period. The...

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Identifiers

PMID: 21593735
DOI: 10.1038/clpt.2011.70

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