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Article

Prognostic impact of p15 gene aberrations in acute leukemia.

Leukemia & lymphoma - 1 Feb 2017

De Braekeleer Marc, Douet-Guilbert Nathalie, De Braekeleer Etienne

Abstract excerpt

The p15 gene (also known as CDKN2B, INK4B, p15INK4B), located in band 9p21, encodes a protein that induces a G1-phase cell cycle arrest through inhibition of CDK4/6 (cyclin-dependent kinase 4/6). It also plays an important role in the regulation of cellular commitment of hematopoietic progenitor cells and myeloid cell differentiation. p15 can be silenced by several mechanisms, including deletion and...

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Share to Cyclin-Dependent Kinase Inhibitor p15
Share to Epigenesis, Genetic
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Leukemia, Myeloid, Acute

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

Identifiers

PMID: 27401303
DOI: 10.1080/10428194.2016.1201574

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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